Thrombin Activity Associated with Neuronal Damage during Acute Focal Ischemia
نویسندگان
چکیده
منابع مشابه
Thrombin activity associated with neuronal damage during acute focal ischemia.
Mechanisms of ischemic neuronal and vascular injury remain obscure. Here we test the hypothesis that thrombin, a blood-borne coagulation factor, contributes to neurovascular injury during acute focal ischemia. Stroke was induced in adult Sprague Dawley rats by occluding the middle cerebral artery. Intra-arterial thrombin infusion during ischemia significantly increased vascular disruption and c...
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Bo Chen,1,3 Beth Friedman,2 Michael A. Whitney,2 Jessica A. Van Winkle,1 I-Farn Lei,1 Emilia S. Olson,2 Qun Cheng,3 Benedict Pereira,1 Lifu Zhao,1 Roger Y. Tsien,2,4,5 and Patrick D. Lyden1,3 1Department of Neurology, Cedars-Sinai Medical Center, Los Angeles, California 90048, and Departments of 2Pharmacology, 3Neuroscience, 4Chemistry and Biochemistry, and 5Howard Hughes Medical Institute, Uni...
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Neuronal damage shortly after onset or after brief episodes of cerebral ischemia has remained difficult to assess with clinical and preclinical imaging techniques as well as with microscopical methods. We here show, in rodent models of middle cerebral artery occlusion (MCAO), that neuronal damage in acute focal cerebral ischemia can be mapped with single-cell resolution using thallium autometal...
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Introduction: Several studies have indicated that late treatment of aminoguanidine (AG) reduces cerebral ischemic injuries in animal models. However, the effects of early treatment of AG on cerebral ischemic damage are not well understood. This study was designed to evaluate effect of early treatment of AG on cortex and striatum injuries as well as neurological dysfunctions in transient mode...
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ژورنال
عنوان ژورنال: Journal of Neuroscience
سال: 2012
ISSN: 0270-6474,1529-2401
DOI: 10.1523/jneurosci.0369-12.2012